RNF7
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[1][2][3]
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]
Interactions
[edit | edit source]RNF7 has been shown to interact with CSNK2B.[4]
See also
[edit | edit source]References
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Further reading
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- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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External links
[edit | edit source]- RNF7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
