RNF216
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.[1]
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.[1]
See also
[edit | edit source]Interactions
[edit | edit source]RNF216 has been shown to interact with TLR9[2] and RIPK1.[3]
References
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Further reading
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External links
[edit | edit source]- RNF216+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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