RNF12
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[2] Functions in female mice as a regulator of X chromosome inactivation .
Interactions
[edit | edit source]RNF12 has been shown to interact with Estrogen receptor alpha.[3]
References
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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