RGS9BP
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Regulator of G protein signaling 9 binding protein is a protein that in humans is encoded by the RGS9BP gene. [1]
Function
[edit | edit source]The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.