RBM3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.[1][2]
Function
[edit | edit source]This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2] RBM3 contains a poison exon whose inclusion is lowered during hypothermia.[3]
RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[4] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[5] and based on confocal microscopy mainly localised to the nucleoplasm.[6]
Clinical significance
[edit | edit source]RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[4] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[7]
References
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Further reading
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