RBBP8

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

DNA repair

RBBP8 is involved in the DNA repair process of homologous recombination. It was proposed that, in gastric cancer cells, inhibition of RBBP8 expression could cause a synthetic lethal effect along with PARP inhibitor treatment.

Interactions

RBBP8 has been shown to interact with:

• ATM,
• BRCA1,
• CTBP1,
• LMO4,
• RB1,
• RBL1,
• RBL2, and
• SIAH1