RAPGEF2
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.[1][2][3]
RAPGEF2 is a cyclic AMP binding protein.[4][5]
Function
[edit | edit source]Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs) such as RAPGEF2 serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.[2]
Interactions
[edit | edit source]RAPGEF2 has been shown to interact with RAP1A[2] and RALGDS.[6]
References
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Further reading
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