RAB3GAP1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Rab3 GTPase-activating protein catalytic subunit is an enzyme that in humans is encoded by the RAB3GAP1 gene.[1][2][3]
Function
[edit | edit source]Members of the RAB3 protein family (see RAB3A; MIM 179490) are implicated in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit and a 150-kD noncatalytic subunit (MIM 609275). RAB3GAP specifically converts active RAB3-GTP to the inactive form RAB3-GDP (Aligianis et al., 2005).[supplied by OMIM][3] RAB3GAP is reported to modulate basal and rapamycin-induced autophagy in human fibroblasts and C. elegans.[4] Further, the RAB3GAP1 knockdown has shown to affect the autophagy and mineralization potential of human primary osteoblasts.[5]
See also
[edit | edit source]- Warburg Micro syndrome
- RAB3GAP2 - the 150-kD noncatalytic subunit of RAB3GAP complex
- Tbc domain
References
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Further reading
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