Pyroglutamyl-peptidase II
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| Pyroglutamyl-peptidase II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.19.6 | ||||||||
| CAS no. | 60063-88-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides
This enzyme is highly specific for thyrotropin releasing hormone.
Human gene
[edit | edit source]TRHDE - thyrotropin releasing hormone degrading enzyme
References
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External links
[edit | edit source]- Pyroglutamyl-peptidase+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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