Peter Colman

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Peter Colman
AC FRS FAA FTSE
File:Professor Peter Colman FRS.jpg
Peter Colman at the Royal Society admissions day in 2014
Born
Peter Malcolm Colman

(1944-04-03) 3 April 1944 (age 82)[5]
Adelaide[3]
Alma mater
Known for
Awards
Scientific career
Fields
Institutions
ThesisThe physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts (1969)
Doctoral advisorHarry Medlin[4]
Websitewww.wehi.edu.au/people/peter-colman

Peter Malcolm Colman (born 1944)[5] is the head of the structural biology division at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia.[7]

Education

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Colman was educated at the University of Adelaide, where he received a Bachelor of Science degree in physics in 1966[5] and a PhD in 1969 for research on the chemical structure of parabanic acid complexes supervised by Harry Medlin.[4]

Research and career

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Colman's research interests are in structural biology,[8][9][10] especially of human B-cell lymphoma 2 (BCL-2).[11][12][13][14] Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir, the first-in-class neuraminidase inhibitor for influenza.[15] His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets.[15] His discoveries underpin drug stockpiling for pandemic preparedness.[15] He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes.[15] Recent[when?] work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane, an essential step in the intrinsic cell-death pathway.[15]

His work has been published in leading peer reviewed scientific journals including Nature,[8][16][17][18][19][20] the Journal of Molecular Biology,[21] and Nature Reviews Molecular Cell Biology.[22]

Awards and honours

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File:CSIRO ScienceImage 2005 Peter Colman and Frank Macfarlane Burnet.jpg
Peter Colman, showing his flu protein (neuraminidase) model to Frank Macfarlane Burnet .

In the Queen's 2017 Birthday Honours Colman was appointed a Companion of the Order of Australia (AC), Australia's highest civilian honour, "for eminent service to medical research, particularly in the fields of structural biology and medicinal chemistry, as a leader in the commercial translation of scientific discoveries, to professional organisations, and as a mentor of young scientists".[23]

Colman was elected a Fellow of the Royal Society (FRS) in 2014.[15] In 2001 he was awarded a Centenary Medal "For service to Australian society and science in structural biology".[2] Colman was also elected a Fellow of the Australian Academy of Science in 1989 and a Fellow of the Australian Academy of Technological Sciences and Engineering in 1997.[5] He was awarded the Lemberg Medal in 1988[24] and the Macfarlane Burnet Medal and Lecture in 1995.[25]

References

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  1. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  2. ^ a b COLMAN, Peter Malcolm - Centenary Medal Archived 7 May 2018 at the Wayback Machine, 1 January 2001, It's an Honour.
  3. ^ a b Peter Malcolm Colman, CSIROpedia Archived 25 October 2015 at the Wayback Machine, Commonwealth Scientific and Industrial Research Organisation
  4. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value). Free access icon
  5. ^ a b c d Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value). (Subscription or UK public library membership required.)
  6. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  7. ^ Peter Colman publications indexed by the Scopus bibliographic database. (subscription required)
  8. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  9. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  10. ^ Type 1 Diabetes Research Update – with Professor Peter Colman on YouTube
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  15. ^ a b c d e f Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value). One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  16. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  23. ^ Companion (AC) in the General Division of the Order of Australia Archived 22 March 2018 at the Wayback Machine, Media Notes, Queen's Birthday 2017, www.gg.gov.au
  24. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).[dead link]
  25. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).

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