PYR-41
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This article may be too technical for most readers to understand. (September 2014) |
| Names | |
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| Preferred IUPAC name
Ethyl 4-{(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoate | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C17H13N3O7 | |
| Molar mass | 371.3 g/mol |
| Density | 1.5±0.1 g/cm3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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PYR-41 is a cell permeable irreversible inhibitor of ubiquitin-activating enzyme E1.[1] It was also reported to increase sumoylation in cells.[1][2]
PYR-41 also blocks the downstream ubiquitination and ubiquitination-dependent protein degradation or other ubiquitination-mediated cellular activities. In addition, PYR-41 inhibits degradation of p53, a tumour suppressor.[3]
References
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