PRM2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Protamine 2 is a protein that in humans is encoded by the PRM2 gene.[1]
Function
[edit | edit source]Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus.
Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015].
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
