Protein kinase, AMP-activated, alpha 1

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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). 5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.[1][2]

The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[2] A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.[3]

Interactions

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Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2.[4][5]

References

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Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

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