KSR2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). KSR2 is a gene which encodes Kinase Suppressor of Ras 2 in humans. [1]
The encoded protein plays a role in energy homeostasis, including fatty acid oxidation, glucose metabolism and basal metabolic rate (BMR). As a result, subsequent mutations in this gene, albeit rare, have been linked to the development of early on-set obesity and insulin resistance.
Variations within the gene and its expression are hypothesized to play a key role in the phenotype of individuals with metabolic disease, alongside leptin-deficiency induced hyperphagia. While the exact mechanism is unclear, it is believed that KSR2 variations result in a disruption of the MAPK/ERK pathway, which can in turn lower the body's BMR. Since this normally accounts for about 70% of the total energy expenditure, a decrease results in excess energy storage, compared to an individual with a normal BMR on an isocaloric diet.[2]
Besides human metabolism, KSR2 is also crucial for ovarian development in the cabbage beetle Colaphellus bowringi.[3]
See also
[edit | edit source]References
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