PPM1B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.[2]
Interactions
[edit | edit source]PPM1B has been shown to interact with:
References
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Further reading
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