POLR3B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). RNA polymerase III subunit B is an enzyme which is encoded by the gene POLR3B is a gene that in humans encodes the second largest subunit of RNA polymerase III.[1]
Gene
[edit | edit source]The POLR3B gene is located on the long arm (q) of chromosome 12 on position 23.3, from base pair from base pair 106,357,748 to base pair 106,510,198.[2]
Function
[edit | edit source]RNA polymerase III essential enzyme complex responsible for synthesizing small non-coding RNAs, including transfer RNAs (tRNAs) and 5S ribosomal RNA (rRNA) and these small RNAs play a critical role in the process of protein synthesis within cells.[3]
Clinical significance
[edit | edit source]Mutations in POLR3B are associated with certain genetic disorders, such as hypomyelinating leukodystrophy and Charcot–Marie–Tooth disease type 1I, highlighting its importance in normal nervous system development and function.[3][4]
References
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