PLAT domain
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| PLAT/LH2 domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the lipase-procolipase complex.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | PLAT | ||||||||
| Pfam | PF01477 | ||||||||
| InterPro | IPR001024 | ||||||||
| SMART | SM00308 | ||||||||
| PROSITE | PDOC50095 | ||||||||
| SCOP2 | 1lpa / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 221 | ||||||||
| OPM protein | 3swz | ||||||||
| CDD | cd00113 | ||||||||
| |||||||||
In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain[2] or LH2 (Lipoxygenase homology) domain.[3] The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.
This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.[2][4][5]
Human proteins containing this domain
[edit | edit source]ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;
References
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