PHC2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene.[1][2][3]
Function
[edit | edit source]In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
[edit | edit source]PHC2 has been shown to interact with MAPKAPK2,[4] PHC1,[1][5] BMI1[1] and MCRS1.[5]
References
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Further reading
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