PEX14

Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
Symbol	Pex14_N
Pfam	PF04695
InterPro	IPR006785
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

Interactions

PEX14 has been shown to interact with

• PEX5,
• PEX7, and
• PEX13.

External links

• GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
• Eukaryotic Linear Motif resource motif class TRG_PEX_1
• Eukaryotic Linear Motif resource motif class TRG_PEX_2
• Overview of all the structural information available in the PDB for UniProt: O75381 (Peroxisomal membrane protein PEX14) at the PDBe-KB.