PEX12
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.[1][2]
Function
[edit | edit source]PEX12 is needed for protein import into peroxisomes.[3] This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes.
Clinical significance
[edit | edit source]The peroxisome biogenesis disorders (PBDs; MIM 601539) are a group of genetically heterogeneous diseases that are usually lethal in early infancy. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. This cellular phenotype is shared by yeast 'pex' mutants, and human orthologs of yeast PEX genes defective in some PBD complementation groups (CGs).[2]
Interactions
[edit | edit source]PEX12 has been shown to interact with PEX10,[4][5] PEX5[4][5] and PEX19.[6][7]
References
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Further reading
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External links
[edit | edit source]- GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
- OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
