PDCD6
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.[1]
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.[2]
Interactions
[edit | edit source]PDCD6 has been shown to interact with ASK1,[3] PDCD6IP,[4][5] Fas receptor,[6] ANXA11[5] and PEF1.[7]
References
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Further reading
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External links
[edit | edit source]- PDCD6 human gene location in the UCSC Genome Browser.
- PDCD6 human gene details in the UCSC Genome Browser.
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