PCGEM1
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| Prostate-specific transcript 1 | |
|---|---|
 Predicted secondary structure and sequence conservation of PCGEM1 | |
| Identifiers | |
| Symbol | PCGEM1 |
| Rfam | RF01981 |
| Other data | |
| RNA type | Gene; |
| Domain | Eukaryota; |
| GO | GO:0042981 |
| SO | SO:0001463 |
| PDB structures | PDBe |
Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.[1][2] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.[3]
PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.[4]
See also
[edit | edit source]References
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Further reading
[edit | edit source]- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).