Optineurin
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Optineurin is a protein that in humans is encoded by the OPTN gene.[1][2][3]
Function
[edit | edit source]This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.[3] OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.[4]
Interactions
[edit | edit source]Optineurin has been shown to interact with Huntingtin[5][6] and RAB8A.[6]
References
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Further reading
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External links
[edit | edit source]- OPTN human gene location in the UCSC Genome Browser.
- OPTN human gene details in the UCSC Genome Browser.