omega-Atracotoxin

ω-Atracotoxin
Identifiers
Symbol	Omega-toxin
Pfam	PF06357
InterPro	IPR009415
SCOP2	1hvw / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1hvwA:4-23 1axh :1-37

omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.

See also

• Atracotoxin

References

This article incorporates text from the public domain Pfam and InterPro: IPR009415