ONECUT1
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One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [1]
Function
[edit | edit source]This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. It is important for the differentiation of pancreas endocrine cells,[2] and mutations in ONECUT1 are involved in juvenile diabetes.[3] Alternative splicing results in multiple transcript variants.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
