Solute carrier organic anion transporter family member 1B3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[1]
OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.
Clinical significance
[edit | edit source]OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[2] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[3]
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[3]
Substrates
[edit | edit source]Small molecules that are transported by SLCO1B3 include:[4]
- Amanitin
- Atrasentan
- Bilirubin
- Bosentan
- BQ-123
- Bromsulphthalein (BSP)
- CDCA-NBD
- Cholate (CA)
- Cholecystokinin octapeptide (CCK-8)
- Dehydroepiandroserone-3-sulfate (DHEAS)
- Deltorphin II
- Demethylphalloin
- Digoxin
- Docetaxel
- [D-penicillamine2,5]enkephalin (DPDPE)
- Enalapril
- Estradiol-17β-glucuronide 5–25
- Estrone-3-sulfate
- Fexofenadine
- Fluvastatin
- Fluo-3
- Glutathione (GSH)
- Glycocholate (GCA)
- Glycoursodeoxycholate (GUDCA)
- Irinotecan
- Leukotriene C4 (LTC4)
- Methotrexate
- Microcystin
- Monoglyucuronosyl
- Olmesartan
- Ouabain
- Paclitaxel
- Phalloidin
- Pitavastatin
- Rifampicin
- Ro 48-5033 (Bosentan metabolite)
- Rosuvastatin
- SN-38
- Taurocholate (TCA)
- Taurochenodeoxycholate (TCDCA)
- Taurodeoxycholate (TDCA)
- Tauroursodeoxycholate (TUDCA)
- Telmisartan
- Thyroxine (T4)
- TR-14035
- Triiodothyronine (T3)
- Valsartan
See also
[edit | edit source]References
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Further reading
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