Nitroxinil
| File:Nitroxinil Structure.svg Structure of nitroxinil | |
| Clinical data | |
|---|---|
| Trade names | Fluconix, Dovenix, Trodax |
| Other names | Nitroxynil |
| Routes of administration | Subcutaneous in the form of an N-Ethylglucamine salt solution |
| ATCvet code | |
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| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C7H3IN2O3 |
| Molar mass | 290.016 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 136–139 °C (277–282 °F) |
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Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle.[1] The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract.[2] Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.[citation needed]
Nitroxinil was invented by May & Baker[3] in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to Nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group.
Nitroxynil is almost insoluble in water. It is usually injected subcutaneously into the animals in the form of the water-soluble ethylglucamine salt.[2] It must not be administered to animals that produce milk for human consumption.[4]
References
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