Nuclear receptor co-repressor 2
(Redirected from NCOR2)
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[1][2] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[1] or T3 receptor-associating cofactor 1 (TRAC-1).[2]
Function
[edit | edit source]NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[1] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[3]
Family
[edit | edit source]It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[4]
Discovery
[edit | edit source]SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[1] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[2]
Interactions
[edit | edit source]Nuclear receptor co-repressor 2 has been shown to interact with:
- AR[5][6][7]
- BCL6[8][9][10]
- C-Fos[11]
- C-jun[11]
- HDAC1[12][13]
- HDAC3[13][14][15][16][17][18][19]
- HDAC4[18][20]
- HDAC5[20]
- HDAC10[12]
- MeCP2[21]
- NR4A1[22]
- POU2F1[23]
- PPARD[24]
- PGR[25]
- PML[26][27]
- RBPJ[28][29]
- RELA[11][30]
- RUNX1T1[31][32]
- RARA[33][34]
- SIN3A[14][20]
- SNW1[35][36]
- SPEN[37]
- SRF[11]
- TBL1X[14][15][16][17]
- THRB[38][39][40]
- VDR[39][41]
- ZBTB16[8][31][34]
References
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- ^ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
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Further reading
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External links
[edit | edit source]- nuclear receptor corepressor 2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C98