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Definition

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Influenza, commonly known as the flu, is an infectious disease caused by an influenza virus.[1]

File:EM of influenza virus.jpg

Symptoms

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The most common symptoms include: high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and feeling tired.[1][2]

File:Symptoms of influenza png whitebackground.png

Timing of symptoms

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These symptoms typically begin two days after exposure to the virus, and most last less than a week.[1] The cough, however, may last for more than two weeks.[1]

File:Influenza symptom chart.png

Symptoms in children

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In children, there may be diarrhea and vomiting, although [3] these symptoms are more commonly caused by the unrelated illness, gastroenteritis (otherwise known as the stomach, or 24 hour flu).[3]

File:Vomiting.jpg

Complications

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Complications of influenza may include viral pneumonia, secondary bacterial pneumonia, sinus infections, and worsening of previous health problems, such as asthma, or heart failure.[4][2]

File:Chest radiograph in influensa and H influenzae, posteroanterior, annotated.jpg

Causes

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Influenza viruses are classified into four types. Types A, B, and C, affect humans.[4][5] Type D does not, but is believed to have the potential for it.[5][6]

File:3D Influenza virus.png

Airborne spread

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Usually, the virus is spread through the air, from coughs or sneezes,[1] over relatively short distances.[7]

File:Medicon cough.svg

Surface spread

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It can also be spread by touching surfaces contaminated by the virus, and then touching the mouth or eyes.[2][7]

File:Contaminated surfaces increase cross-transmission.jpg

Infectious period

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A person may be infectious to others both before, and during, the time they are showing symptoms.[2]

File:Ferguson influenza generation time distribution.png

Diagnosis

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The infection may be confirmed by testing the throat, sputum, or nose for the virus[4] with a rapid test, although people may still have the infection even if the results are negative.[4]

File:Exam clinique - gorge - CDC 10189.jpg

Prevention

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Frequent hand washing, or wearing a surgical mask, reduces the risk of viral spread.[8][8]

File:Clean hands short.webm

Vaccination

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Yearly vaccinations against influenza are recommended by the World Health Organization, for those at high risk.[1]

File:A nurse vaccinates Barack Obama against H1N1.jpg

Vaccine effectiveness

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The vaccine is usually effective against three or four types of influenza,[1] is usually well-tolerated,[1] but only effective for a single season, since the virus evolves rapidly.[1]

File:ReverseGeneticsFlu.svg

Antiviral drugs

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Antiviral drugs such as the neuraminidase inhibitor oseltamivir, have been used to treat influenza,[1] but the benefit to otherwise healthy patients does not appear to be greater than the risks,[9] and no benefit has been found in those with other health problems.[9][10]

File:Tamiflu.JPG

Epidemiology

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Influenza spreads around the world in yearly outbreaks, resulting in three to five million cases of severe illness, and 250 to 500 thousand deaths.[1] About 20% of unvaccinated children, and 10% of unvaccinated adults are infected each year.[11]

Geography

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In the northern and southern parts of the world, outbreaks occur mainly in the winter, while around the equator, outbreaks may occur at any time of the year.[1]

Highest risk of death

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Death occurs mostly in the young, the old, and those with other health problems.[1] Larger outbreaks, known as pandemics, are less frequent.[4]

History

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In the 20th century, three influenza pandemics occurred.

Spanish flu

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The Spanish influenza in 1918 that resulted in 50 million deaths,

Asian influenza

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The Asian influenza in 1957 that killed two million,

Hong Kong influenza

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and Hong Kong influenza in 1968, that resulted in one million deaths.[12]

File:USS Ingersoll (DD-652) at Hong Kong in 1968.jpg

Swine flu

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The World Health Organization declared an outbreak of a new type of influenza A, called H1N1, or swine flu, that resulted in a pandemic during 2009, and 2010.[13]

File:H1N1 versus H5N1 pathology.png

Other animals

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Influenza may also affect other animals, including pigs, horses, and birds.[14]

File:Avian influenza roee shpernik 06.jpg

References

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