Motixafortide
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| Clinical data | |
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| Trade names | Aphexda |
| Other names | BL-8040 |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Subcutaneous |
| Drug class | Antineoplastic |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C97H144FN33O19S2 |
| Molar mass | 2159.55 g·mol−1 |
Motixafortide, sold under the brand name Aphexda, is a medication used for the treatment of multiple myeloma.[1] Motixafortide is a hematopoietic stem cell mobilizer and a CXCR4 antagonist.[1] It is given by subcutaneous injection.[1]
The most common side effects include injection site reactions, pruritus, flushing, and back pain.[3]
Motixafortide was approved for medical use in the United States in September 2023.[3][4][5]
Medical uses
[edit | edit source]Motixafortide is indicated, in combination with filgrastim, a granulocyte-colony stimulating factor (G-CSF), to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in people with multiple myeloma.[1][3][4]
Adverse effects
[edit | edit source]Motixafortide can cause injection site reactions, anaphylactic shock, and hypersensitivity reactions.[3] Tumor cell mobilization in people with leukemia, leukocytosis, potential for tumor cell mobilization, and embryo-fetal toxicity can also be caused by motixafortide.[3]
History
[edit | edit source]The US Food and Drug Administration (FDA) approved motixafortide based on evidence from the GENESIS study, a double-blind, placebo-controlled study, in which 122 participants with multiple myeloma, due to undergo autologous transplantation, were randomized 2:1 to receive motixafortide 1.25 mg/kg with granulocyte-colony stimulating factor (N=80) or placebo with granulocyte-colony stimulating factor (N=42) for mobilization of hematopoietic stem cells for collection and apheresis.[3] This one trial evaluated the benefit and side effects of motixafortide in participants.[3] The trial was conducted at 21 sites in five countries including Italy, Hungary, Germany, Spain, and the United States.[3] There were 78 participants included in the trial from the United States, and 44 participants included from sites outside of the United States.[3] The GENESIS trial was used to assess efficacy and safety.[3]
Society and culture
[edit | edit source]Names
[edit | edit source]Motixafortide is the international nonproprietary name.[6]
References
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Further reading
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External links
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- Clinical trial number NCT03246529 for "A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and G-GSF as Compared to Placebo and G-CSF for thE MobilizatioN of HematopoiEtic Stem Cells for Autologous TransplantatIon in SubjectS With MM (GENESIS)" at ClinicalTrials.gov
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