Mengla dianlovirus
| Mengla dianlovirus | |
|---|---|
| Virus classification Edit this classification | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Monjiviricetes |
| Order: | Mononegavirales |
| Family: | Filoviridae |
| Genus: | Dianlovirus |
| Species: | Mengla dianlovirus
|
| Synonyms | |
| |
Mengla dianlovirus (MLAV, also written Měnglà virus) is a type of filovirus identified in a Rousettus bat in Mengla County, Yunnan Province, China, and was first reported in January 2019.[1] It is classified in the same family as Ebolavirus and Marburgvirus.[2]
It is the only member of the genus Dianlovirus.[1] The name derives from 滇 (diān), the Chinese language abbreviation for Yunnan, added to "filovirus", the common name for Filoviridae.[1] Neither the species nor the genus are listed in the 2018 ICTV classification, as the virus was formally described after that report was released.[3] A formal proposal was submitted for the taxa in January 2019.[4]
MLAV proteins, including VP35 and VP40, inhibit host immune responses by interfering with interferon signaling, contributing to immune evasion similar to other filoviruses.[5] Like other filoviruses, Mengla virus utilizes the Niemann-Pick C1 (NPC1) receptor for cell entry, a trait that may facilitate cross-species transmission.[6]
References
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