Mark B. Gerstein

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Mark Gerstein
Born
Mark Bender Gerstein

February 23
CitizenshipUS
Alma mater
Awards
Scientific career
FieldsBioinformatics[4]
Institutions
ThesisProtein recognition: surfaces and conformational change (1993)
Doctoral advisor
Other academic advisorsMichael Levitt (postdoc)
Doctoral studentsWerner Krebs[7][8]
Other notable studentsJan O. Korbel
Website

Mark Bender Gerstein is an American scientist working in bioinformatics and data science. He is the Albert L. Williams Professor of Biomedical Informatics, professor of molecular biophysics & biochemistry, professor of statistics & data science, and professor of computer science at Yale University.[9] He is also co-director of the Yale Computational Biology and Bioinformatics program. In 2018, Gerstein was named co-director of the Yale Center for Biomedical Data Science.[10]

Education

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After graduating from Harvard College summa cum laude with a Bachelor of Arts in physics in 1989, Gerstein did a PhD co-supervised by Ruth Lynden-Bell[6] at the University of Cambridge and Cyrus Chothia at the Laboratory of Molecular Biology on liquid simulation and macromolecular conformational change in proteins, graduating in 1993.[11] He then went on to postdoctoral research in bioinformatics at Stanford University from 1993 to 1996 supervised by Nobel-laureate Michael Levitt.

Research

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Gerstein does research in the field of bioinformatics.[4][12][13] This involves applying a range of computational approaches to problems in molecular biology, including data mining and machine learning, molecular simulation, and database design. His research group has a number of foci including annotating the human genome,[14] personal genomics, cancer genomics, building AL/ML tools, analyzing molecular networks, simulating macromolecular motions, and processing biosensor and imaging data. Notable databases and tools that the group has developed include the Database of Macromolecular Motions,[7][8] which categorizes macromolecular conformational change; tYNA,[15] which helps analyze molecular networks; PubNet,[16] which analyzes publication networks; PeakSeq,[17] which identifies regions in the genome bound by particular transcription factors; and CNVnator,[18] which categorizes block variants in the genome. Gerstein has also written extensively on how general issues in data science impact on genomics—in particular, in relation to privacy[19] and to structuring scientific communication.[20]

Gerstein's work has been published in peer reviewed scientific journals[21][22][23] and non-scientific publications in more popular forums.[24] His work has been highly cited, with an H greater than 200.[4] He serves on a number of editorial and advisory boards, including those of PLoS Computational Biology, Genome Research, Genome Biology, and Molecular Systems Biology. He has been quoted in the New York Times,[25][26][27] including on the front page,[14] and in other major newspapers.[28]

Awards and honors

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In addition to a W. M. Keck Foundation Distinguished Young Scholars award,[29] Gerstein has received awards from the US Navy, IBM, Pharmaceutical Research and Manufacturers of America, and the Donaghue Foundation.[30] He is a Fellow of the AAAS.[1] Other awards include a Herchel-Smith Scholarship supporting his doctoral work at Emmanuel College, Cambridge and a Damon Runyon Cancer Research Foundation Postdoctoral Fellowship. He is a contributor to a number of scientific consortia including ENCODE,[31] modENCODE,[32][33][34] 1000 Genomes Project, Brainspan,[35] and DOE Kbase.[citation needed] He was made a Fellow of the International Society for Computational Biology (ISCB) in 2015 [2] and also received an Accomplishments by a Senior Scientist Award from the ISCB in 2023.[3]

References

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  1. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  4. ^ a b c Mark B. Gerstein publications indexed by Google Scholar
  5. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  6. ^ a b Mark B. Gerstein at the Mathematics Genealogy Project
  7. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  8. ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  9. ^ Mark B. Gerstein's publications indexed by the Scopus bibliographic database. (subscription required)
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  14. ^ a b Gina Kolata, (Sept. 5, 2012) 'Bits of Mystery DNA, Far From Junk, Play Crucial Role,' NY Times
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  21. ^ Mark Gerstein at DBLP Bibliography ServerLua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
  22. ^ Mark B. Gerstein publications indexed by Microsoft Academic
  23. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  35. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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