Mantle zone

Mantle zone
Mantle zone
	File:Dark, light, mantle and marginal zones of a secondary follicle.png Histology of a normal secondary lymphoid follicle, with yellow arrows pointing at the mantle zone.
Identifiers
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TH	{{#property:P1694}}
TE	{{#property:P1693}}
FMA	{{#property:P1402}}
	Anatomical terminology [[[d:Lua error in Module:Wikidata at line 865: attempt to index field 'wikibase' (a nil value).\|edit on Wikidata]]]

Image labeled in German, but "Mantel-zone" visible near center

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.^[1]

It is also known as the "corona".^[2]

It contains transient lymphocytes.^[3]

It is the location of the lymphoma in mantle cell lymphoma.

Pathology

Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.

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https://web.archive.org/web/20080813003821/http://erl.pathology.iupui.edu/HISTO/LABE109.HTM
Histology image: 07102loa – Histology Learning System at Boston University — "Lymphoid Tissues and Organs: lymph node, cortex and medulla"