MID2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Midline-2 is a protein that in humans is encoded by the MID2 gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]
Recent reports indicate the involvement of MID2 in cytokinesis [3][4].MID2 (TRIM1) ubiquitinates Sperm-associated antigen 5 (Astrin) on K409, further promoting its degradation and proper cytokinesis.[4] In contrary, depletion of MID2 (TRIM1) stabilizes Sperm-associated antigen 5 (Astrin) whose inappropriate accumulation at the midbody triggers cytokinetic arrest, multinucleated cells, and cell death.[3][4]
Interactions
[edit | edit source]MID2 has been shown to interact with MID1.[5][6]
MID2 (TRIM1) interacts with Leucine-rich repeat kinase 2 (LRRK2), which is often subject to missense mutations in familial Parkinson's disease (PD).[7] MID2 (TRIM1) specifically binds to the flexible regulatory loop of LRRK2853–981.[7] MID2 (TRIM1) recruits LRRK2 to the microtubule cytoskeleton where MID2 (TRIM1) ubiquitinates LRRK2 targeting it for proteasomal degradation.[7]
References
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Further reading
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