MFSD8
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Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the MFSD8 gene.[1] MFSD8 is an atypical SLC,[2][3] thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 (AMTF2).[3]
Function
[edit | edit source]MFSD8 is a ubiquitous integral membrane protein which contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein, likely localizes to lysosomal membranes.[4]
Clinical significance
[edit | edit source]Mutations in the MFSD8 gene have been of neuronal ceroid lipofuscinosis.[5]
References
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External links
[edit | edit source]Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
