MAP2K2

Main article: Mitogen-activated protein kinase kinase

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

Interactions

MAP2K2 has been shown to interact with MAPK3 and ARAF.

External links

• GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome
• Overview of all the structural information available in the PDB for UniProt: P36507 (Dual specificity mitogen-activated protein kinase kinase 2) at the PDBe-KB.