MED28
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| Med28 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med28 | ||||||||
| Pfam | PF11594 | ||||||||
| InterPro | IPR021640 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[1][2][3] It forms part of the Mediator complex.
Function
[edit | edit source]Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[4]
Interactions
[edit | edit source]MED28 has been shown to interact with Merlin,[2] Grb2[2] and MED26.[5]
See also
[edit | edit source]References
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Further reading
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