MALAT1
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| Conserved secondary structure in Metastasis associated lung adenocarcinoma transcript 1 | |
|---|---|
| File:MALAT1 secondary structure.jpg Predicted secondary structure and sequence conservation of MALAT1 | |
| Identifiers | |
| Symbol | MALAT1 |
| Rfam | RF01871 |
| Other data | |
| RNA type | Gene; |
| Domain | Eukaryota; |
| GO | GO:2000147 |
| SO | SO:0001263 |
| PDB structures | PDBe |
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus.[1] It regulates the expression of metastasis-associated genes.[2] It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes.[3] MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).[4]
Expression in alcoholic brains
[edit | edit source]Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.[5]
Prognostic potential in cancer
[edit | edit source]Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.[6][7]
See also
[edit | edit source]References
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Further reading
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