MAGI2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.[1][2][3]
Function
[edit | edit source]The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[3]
Interactions
[edit | edit source]MAGI2 has been shown to interact with ATN1[4] and PTEN (gene).
References
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Further reading
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