MAD1L1

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.

MAD1L1 is also known as Human Accelerated Region 3. It may have played a key role in the evolution of humans from apes.

Function

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Some studies indicate associations of MAD1L1 with psychiatric disorders, including schizophrenia, bipolar disorder, and depression. Three transcript variants encoding the same protein have been found for this gene.

Interactions

MAD1L1 has been shown to interact with:

• HDAC1,
• Histone deacetylase 2, and
• MAD2L1,

See also

• MAD1
• MAD2
• Hyperphosphorylation