Loricrin
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Loricrin is a protein that in humans is encoded by the LOR gene.[1][2][3]
Function
[edit | edit source]Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.[3]
Loricrin is expressed in the granular layer of all keratinized epithelial cells of mammals tested including oral, esophageal and stomach mucosa of rodents, tracheal squamous metaplasia of vitamin A deficient hamster and estrogen induced squamous vaginal epithelium of rats.[4]
Clinical significance
[edit | edit source]Mutations in the LOR gene are associated with Vohwinkel's syndrome and Camisa disease, both inherited skin diseases.
See also
[edit | edit source]References
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Further reading
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