LEFTY2
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Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans. [1]
Function
[edit | edit source]Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.[2][3] It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.
Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).[2] Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.
Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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