Kinamycin
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Kinamycins are a group of bacterial polyketide secondary metabolites containing a diazo group. Kinamycins are known for their cytotoxicity and are considered of interest for potential use in anti-cancer therapies.[1][2]
Synthesis
[edit | edit source]In 2006 and 2007 the means to totally and enantioselectively synthesize kinamycins C, F, and J were discovered.[3][4] In 2010 a method was found to allow easier synthesis of these compounds in fewer steps, making research into their properties more feasible.[5]
References
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External links
[edit | edit source]- EMBL-EBI listing—includes links to structural formula and other properties of group members kinamycin (CHEBI:48207)
- Description of Porco(2006) and Nicolaou(2007) synthesis on University of Pittsburgh site