KREMEN1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene.[1][2] Kremen1 is conserved in chordates including amphioxus[3] and most vertebrate species.[4] The protein is a type I transmembrane receptor of ligands Dickkopf1,[5] Dickkopf2, Dickkopf3, Dickkopf4, EpCAM[6] and Rspondin1.
Function
[edit | edit source]This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular Kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.[2]
Kremen1 also has a function in the induction of cell death by apoptosis.[4] This proapoptotic activity is conditional and depends on the absence of ligand Dickkopf1.[4] These observations led to the classification of this protein as a Dependence Receptor.
A mouse knock out of Kremen1 and its paralog Kremen2 is viable and fertile.[7]
References
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Further reading
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