KIRREL3
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Kin of IRRE-like protein 3 (KIRREL3) also known as kin of irregular chiasm-like protein 3 or NEPH2 is a protein that in humans is encoded by the KIRREL3 gene.[1]
NEPH2 is a member of the NEPH protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). The NEPH proteins can interact with nephrin and CASK.
Function
[edit | edit source]NEPH2 has been implicated in synapse formation.[2] Disruption of KIRREL3 gene function had been associated with abnormal brain function.[3]
NEPH1 and NEPH2 are involved in the blood filtration function of the kidney and are located in the slit diaphragm.[4]
References
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Further reading
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