Jean Bennett

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For the first woman president of The Optical Society, see Jean M. Bennett.

Jean Bennett is the F. M. Kirby Professor of Ophthalmology in the Perelman School of Medicine at the University of Pennsylvania. Her research focuses on gene therapy for retinal diseases. Her laboratory developed the first FDA approved gene therapy for use in humans, which treats a rare form of blindness. She was elected a member of the National Academy of Sciences in 2022.[1]

Education

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Bennett attended Hopkins School in New Haven,[2] and graduated with honors from Yale University in 1976, with a bachelor of science in biology. Her father, William R. Bennett Jr., was a member of the faculty there. Her brother is William Bennett (oboist). In 1980, she obtained a Doctorate of Philosophy in Zoology; Cell And Development Biology from the University of California, Berkeley. Bennett continued on to Harvard University to receive her Doctor of Medicine (MD) in 1986.

Career

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Early research

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Bennett received her PhD in Zoology from the University of California, Berkeley in 1980 under Dr. Daniel Mazia. Her graduate research focused on the early development of sea urchin embryos. She moved on to postdoctoral work at the University of California, San Francisco under the guide of Dr. Roger Pedersen. As a postdoctoral student, she collaborated with Dr. William French Anderson developing molecular techniques for gene editing. In 1982, she left this position to attend medical school at Harvard University.[3]

At Harvard, Bennett studied human genetics with Leon Rosenberg and Wayne Fenton (Yale), and she also investigated Down's syndrome and Alzheimer's disease with John Gearhart, Mary Lou Oster-Granite, and Roger Reeves (Johns Hopkins). From this work, she was awarded a career development grant from the Foundation Fighting Blindness to begin research on gene therapy for retinitis pigmentosa (genetic blindness).

Development of Luxturna

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To develop an effective gene therapy in the retina, Bennett started by investigating adenoviruses and adeno-associated viruses (AAV) for gene editing in mice and non-human primates at the Institute for Human Gene Therapy at the University of Pennsylvania.[4][5][6][7] The field of gene therapy was stymied after the death of Jesse Gelsinger during 1999 in a clinical trial for gene editing.[8] However, Bennett pushed forward and demonstrated that AAV-mediated delivery of a functional RPE65 gene significantly improved sight in near-blind dogs.[9]

Based on their pre-clinical data, Bennett's team pursued clinical trials in children with a defective form of the RPE65 gene. Their initial trials showed a stark improvement in light sensitivity and visual function in these children.[10][11][12][13] Based on this, the therapy, marketed as LUXTURNA®, was approved by the FDA for use in humans. Currently, her laboratory is investigating gene therapy approaches for other retinal diseases.[14][15][16]

Awards and patents

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Awards

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Patents

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  • Method of treating or retarding the development of blindness, (2012).[20]
  • Methods, systems, and computer readable media for testing visual function using virtual mobility tests, (2019).[21]
  • Trans-viral vector mediated gene transfer to the retina, (abandoned).[22]
  • Modified AAV8 capsid for gene transfer for retinal therapies, (2015).[23]
  • Proviral plasmids and production of recombinant adeno-associated virus, (2016).[24]
  • Method of treating or retarding the development of blindness, (abandoned).[25]
  • Gene therapy for ocular disorders, (2018).[26]
  • Gene therapy for treating peroxisomal disorders, (2018).[27]
  • Trans-splicing molecules, (2019).[28]
  • Gene therapy for ocular disorders, (2018).[29]
  • Syringe actuator, (2010).[30]
  • Methods and compositions for treatment of disorders and diseases involving RDH12, (2019).[31]
  • Gene therapy for ocular disorders, (2018).[32]
  • Enhanced AAV-mediated gene transfer for retinal therapies, (2019).[33]
  • Synergistic combination of neuronal viability factors and uses thereof, (2020).[34]
  • AAV vectors expressing Sec10 for treating kidney damage, (abandoned).[35]
  • Methods and compositions for treatment of ocular disorders and blinding diseases, (2020).[36]
  • Apparatus and methods for testing visual function and functional vision at varying luminance levels, (2019).[37]
  • Compositions and methods for correction of heritable ocular disease, (2021).[38]
  • Vision test for determining retinal disease progression, (2021).[39]
  • Compositions and methods for self-regulated inducible gene expression, (2019).[40]
  • AAV7 viral vectors for targeted delivery of RPE cells (Application PCT/US2009/041606)[41]
  • Method for transducing cells with primary cilia, (2020).[42]
  • Compositions and methods for treatment of disorders related to CEP290, (2018).[43]

References

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  1. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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  19. ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
  20. ^ US 8147823, Acland, Gregory M.; Aguirre, Gustavo D. & Bennett, Jean et al., "Method of treating or retarding the development of blindness", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania, University of Florida Research Foundation Inc. and Cornell Research Foundation Inc. 
  21. ^ WO application 2019210087, Bennett, Jean; Aleman, Tomas S. & Ashtari, Manzar et al., "Methods, systems, and computer readable media for testing visual function using virtual mobility tests", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  22. ^ US 2003003582, Wakefield, John & Bennett, Jean, "Trans-viral vector mediated gene transfer to the retina", issued Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to Tranzyme Inc. 
  23. ^ EP 2954051, Cronin, Therese; Bennett, Jean & Vandenberghe, Luk E., "Modified AAV8 capsid for gene transfer for retinal therapies", issued Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  24. ^ US 9249425, Bennett, Jean & Bennicelli, Jeannette L., "Proviral plasmids and production of recombinant adeno-associated virus", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania & inventors 
  25. ^ WO 02082904, Acland, Gregory M.; Aguirre, Gustavo D. & Bennett, Jean et al., "Method of treating or retarding the development of blindness", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania, University of Florida Research Foundation Inc. and Cornell Research Foundation Inc. 
  26. ^ WO application 2018232149, Bennett, Jean; Sun, Junwei & Bennicelli, Jeannette, "Gene therapy for ocular disorders", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  27. ^ WO application 2018218359, Bennett, Jean; Sun, Junwei & Song, Ji Yun et al., "Gene therapy for treating peroxisomal disorders", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania, the inventors, Nancy Braverman, Catherine Argyriou and Joseph Hacia 
  28. ^ WO application 2019204514, Johnson, Philip R.; SCchnepp, Bruce C. & Bennett, Jean et al., "Trans-splicing molecules", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania and Limelight Bio Inc. 
  29. ^ WO application 2018200542, Bennett, Jean; Sun, Junwei & Shindler, Kenneth et al., "Gene therapy for ocular disorders", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  30. ^ WO application 2010088259, Borghuis, Bart; Letterio, Fred & Bennett, Jean, "Syringe actuator", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania & inventors 
  31. ^ US application 2019151473, Bennett, Jean; Sun, Junwei & Vasireddy, Vidyullatha, "Methods and compositions for treatment of disorders and diseases involving RDH12", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  32. ^ WO application 2018160849, Bennett, Jean; Bennicelli, Jeannette & Sun, Junwei et al., "Gene therapy for ocular disorders", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  33. ^ US 10266845, Cronin, Therese; Bennett, Jean & Vandenberghe, Luk E., "Enhanced AAV-mediated gene transfer for retinal therapies", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  34. ^ US 10668129, Leveillard, Thierry; Flannery, John & Mei, Xin et al., "Synergistic combination of neuronal viability factors and uses thereof", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, The Regents of the University of California & The Trustees of the University of Pennsylvania 
  35. ^ US 20150374851, Lipschutz, Joshua H.; Bennett, Jean & Chung, Daniel C., "AAV vectors expressing Sec10 for treating kidney damage", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  36. ^ US 10857240, Bennicelli, Jeannette; Bennett, Jean & Sun, Junwei, "Methods and compositions for treatment of ocular disorders and blinding diseases", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  37. ^ US 10448823, High, Katherine A.; Bennett, Jean & Chung, Daniel et al., "Apparatus and methods for testing visual function and functional vision at varying luminance levels", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Children's Hospital of Philadelphia and The Trustees of the University of Pennsylvania 
  38. ^ US 10987433, Bennett, Jean; Bennicelli, Jeannette & Dooley, Scott J. et al., "Compositions and methods for Correction of Heritable Ocular Disease", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania and Lloyd G. Mitchell 
  39. ^ US 11206977, Bennett, Jean, "Vision test for determining retinal disease progression", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  40. ^ US 10392622, Lewis, Mitchell; Bennett, Jean & Vandenberghe, Luk et al., "Compositions and methods for self-regulated inducible gene expression", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 
  41. ^ WO application 2009134681, Wilson, James M.; Vandenberghe, Luc H. & Bennett, Jean et al., "AAV7 viral vectors for targeted delivery of RPE cells", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania and Smithkline Beecham Corp. & inventors 
  42. ^ US 10696983, Bennett, Jean & Lipschutz, Joshua, "method for transducing cells with primary cilia", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania and inventors 
  43. ^ US 10155794, Drivas, Theodore G. & Bennett, Jean, "Compositions and methods for treatment of disorders related to CEP290", published Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value)., assigned to The Trustees of the University of Pennsylvania 

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