Insulin receptor substrate
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Insulin receptor substrates (IRS) are important ligands in the insulin response of human cells.
IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.
Genes
[edit | edit source]- IRS1 (see also Insulin receptor substrate 1)
- IRS2 (see also Insulin receptor substrate 2)
- IRS3P - a pseudogene
- IRS4
References
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