Inidascamine

Inidascamine
	File:Inidascamine.svg
Clinical data
Other names	RL-007; RL007; FSV7-007
Routes of; administration	Oral
Identifiers
	IUPAC name (2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-ylpropan-1-one;
CAS Number	903884-71-9;
PubChem CID	11535990;
ChemSpider	9710771;
UNII	3LW01V88B7;
ChEMBL	ChEMBL5095258;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C12H17N3O2
Molar mass	235.287 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(C1)C(=O)[C@@H]([C@H](C2=CC=NC=C2)O)N;
	InChI InChI=1S/C12H17N3O2/c13-10(12(17)15-7-1-2-8-15)11(16)9-3-5-14-6-4-9/h3-6,10-11,16H,1-2,7-8,13H2/t10-,11+/m1/s1; Key:GRZMKKUGHIECFK-MNOVXSKESA-N;

Inidascamine (INNTooltip International Nonproprietary Name; developmental code names RL-007, FSV7-007) is an experimental drug which is under development for the treatment of cognitive impairment associated with schizophrenia (CIAS).^[1]^[3]^[4]^[5]^[6]^[2] It is taken orally.^[1]^[2] The drug is said to act on the cholinergic, NMDA, and GABA_B receptor systems.^[1]^[5]^[2] Inidascamine is being developed by Recognify Life Sciences and atai Life Sciences.^[1]^[3] It was discovered via screening of compounds for effects on synaptic plasticity and cognition.^[2] The drug shows structural similarities to phenethylamines and amphetamines.^[7]

References

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^ ^a ^b ^c ^d ^e Donello JE, Walker GA, Schweighoffer F, and Pando MP. Abstract Number: 149. RL-007, a novel oral neuromodulator, enhances synaptic plasticity and cognition in non-clinical models. American College of Neuropsychopharmacology (ACNP) annual meeting. December 5, 2023. https://ir.atai.life/static-files/06c60339-e93c-42fc-9323-c0e38e83f86e
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