Indusatumab vedotin
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| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | Guanylate cyclase 2C |
| Clinical data | |
| Other names | MLN-0264, 5F9vcMMAE |
| Routes of administration | Intravenous |
| ATC code |
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| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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| UNII | |
| E number | {{#property:P628}} |
| CompTox Dashboard (EPA) |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Molar mass | ~150 kg/mol |
Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer[1] and other gastrointestinal cancers.[2] It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).[3]
It was in Phase II clinical trials as of February 2016[update]. The trials were terminated in 2017 because of insufficient efficacy.[1][2][4]
References
[edit | edit source]- ^ a b Clinical trial number NCT02202785 for "A Study of MLN0264 in Patients With Pancreatic Cancer" at ClinicalTrials.gov
- ^ a b Clinical trial number NCT02202759 for "A Study of MLN0264 in Patients With Cancer of the Stomach or Gastroesophageal Junction" at ClinicalTrials.gov
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
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