IMPDH2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.[1][2][3]
Function
[edit | edit source]IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.[1] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A.[4]
Clinical significance
[edit | edit source]This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.[1]
See also
[edit | edit source]References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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